"A lot of people love Thanksgiving turkey, but I save my prime meal-estate for stuffing! Mm-mmm stuffing!"
It can also refer to the biggest portion of a meal, or the part that fills you up the most. I just got a sandwich and fries from Louie's Lunch. The sandwich is kinda small, but they give you so many fries they could fill a plate by themselves. So the prime meal-estate is the fries. The sandwich is almost an appetizer.